It is the story of an inventor, Hugh McVey, who rises from poverty on the bank of the Mississippi River. The novel shows the influence of industrialism on the rural heartland of America.
Winesburg, Ohio begins with a sort of prologue, in which an old writer imagines all the people he has known as grotesques, warped in their pursuits of various truths. A series of stories ensues, each concerned with a single resident of Winesburg.